Technology

Informing the Brightest Minds

Aggregating several quantum dots into a protective polymer envelope, MultiDots provide a brighter, longer-lasting signal with sharp peaks that wipe the ambiguity out of your research. Now imagine all that with magnetic capabilities—allowing you to concurrently observe and manipulate analytes.

We wanted to create a reliable probe that could stand up to the rigors of the lab and produce a fuller, sharper picture of biological interactions over time. Encouraged by their brightness and general durability, we’ve been convinced that the nanocrystals in quantum dots held the key.

Core Quantum Technologies was founded to overcome the technology’s inherent limitations. And we have. Our micelle-encapsulated nanocrystals provide unblinking and long-lasting insight into nanoscale activity. Improving the quality of your data, so you can improve the quality of human life.

Photostability

Photostability

Protected by their polymer coating, MultiDots provide more photostability than existing quantum dots. Now you can store tagged cells and re-examine them later, without losing signal to photobleaching. When compared to Alexa dyes and other organic dyes, such as FITC, MultiDots do not photobleach when using powerful lasers, such in confocal microscopy.

Brightness and Excitation

Brightness and Excitation

At 5X the brightness of conventional quantum dots, MultiDots produce a powerful signal, even in photon-limited environments. The broad absorption spectrum shared by MultiDots of all colors means you can perform multiplex studies with a single light source. Meanwhile, the sharp spectral peaks produced will ensure your results are clear of emission overlap.

Access

Although composed of several quantum dots, water-soluble MultiDots remain small enough to access the areas you need.

“…our electron microscopy has shown these novel nanoparticles can indeed get access to the myofilament lattice within muscle cells.” Prof. Beth Brainerd, Professor of Medical Science, Brown University

Publications

Fluorescent and Magnetic

Fluorescent and Magnetic

Tag and separate rare targets while simultaneously evaluating cell surface expression. MagDots combine the enduring signal of MultiDots with superparamagnetic iron oxide nanoparticles (SPION) for sophisticated multimodal analyses. MagDots bring fluorescence and magnetism together at last.

Constant Signal

Constant Signal

The MultiDot format ensures there is a constant signal, even when individual dots within the polymer blink. This allows you to follow a target’s trajectory without drawing dotted lines. The MultiDot’s alternating color also helps microscopists determine when targets are leaving the focal plane or when they aggregate with other targets.

Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science FoundationAny opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation

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