MagDot 610 nm CD4 – 20 Tests

$350.00

The MagDot is a duel-purpose reagent, it combines quantum dots and superparamagnetic iron oxide particles within the same nanoparticle. Cells labeled with MagDots targeting specific antigens will be both fluorescent and magnetic. Therefore, after labeling cells of interest, one can look at the feed to determine the percent positive fluorescently via flow cytometry, and then place the labeled cells in a magnetic separator and analyze both the magnetic (for the enrichment) and the nonmagnetic (for the depletion) of targeted cells without the need for further fluorescent labeling.

These MagDots are conjugated to the OKT4 monoclonal antibody which specifically binds to the CD4 receptor for the human immunodeficiency virus (HIV). CD4 is a 59 kDa single-chain transmembrane glycoprotein that expressed on the surface of most of the thymocytes, T-helper cells, and in low levels on monocytes and macrophages. CD4 is a co-receptor in the antigen-induced T cell activation (together with the MHC class II). The OKT4 and the RPA-T4 monoclonal antibodies recognize different epitopes of CD4 and they do not exhibit cross-block binding.

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Description

Product Information

Size

20 tests

Dilution*

20 µL/million cells

Host/Isotype

Mouse/IgG1

Class

Monoclonal

Type

Antibody

Clone

OKT4

Immunogen

Human CD4

Conjugate

610 nm MagDot

Form

Liquid

Purification

Purified

Storage Buffer

Borate, pH 7.4 with 0.5% BSA and 0.1% sodium azide

Storage Conditions

4˚C do not freeze

Reactivity

Human

Tested Application

Flow Cytometry and Magnetic Separation

Batch

Refer to lot on vial

*Suggested working dilution is given as a guide only.

It is recommended the user titrate the product for use in their own

experiment using appropriate negative and positive controls.

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